McSquiddles is candy and the first product sold by McFist Industries. Father McFist created them.
- The 50th anniversary of McSquiddles and McFist Industries is celebrated in "McOne Armed and Dangerous".
- The first McSquiddle (which was meat-flavored) was saved by Hannibal McFist. When McFist is stanked by the Sorcerer, the McSquiddle is the thing he holds must dear and Randy has to destroy.
- In "House of 1,000 Boogers", McSquiddles are used as fireworks at Bash's party, and although they are hot, Randy and Howard eat them as they fall from the sky.
- Randy spills McSquiddles and a soda onto the 6D Projector in "Grave Puncher: The Movie!", which causes the film to become 7D.